Stop These Medications Now Due To Risk Of Tardive Dyskinesia

Health

By: , 03/19/2024

More than 500,000 people in the USA are dealing with the debilitating disease known as Tardive Dyskinesia which is now known it can be caused by medications.


tardive dyskinesia

What is Tardive Dyskinesia?

Tardive Dyskinesia is a condition characterized by involuntary and repetitive movements of the face, tongue, lips, and other parts of the body.1 These movements can range from mild to severe and may include lip smacking, tongue protrusion, grimacing, rapid eye blinking, and jerking or twisting of the limbs. It occurs due to long-term use of medications that affect the brain’s dopamine system, leading to alterations in the regulation of movement.

What Medications Can Cause Tardive Dyskinesia?

Tardive Dyskinesia (TD) is a condition characterized by involuntary movements, often involving the face, lips, tongue, trunk, and extremities. It is associated with the use of certain medications, particularly antipsychotic drugs. Here are some medications that can cause Tardive Dyskinesia:

  • First-generation antipsychotics (typical antipsychotics): These include medications such as haloperidol, chlorpromazine, fluphenazine, and thioridazine.
  • Second-generation antipsychotics (atypical antipsychotics): Although they are less likely to cause TD compared to first-generation antipsychotics, some atypical antipsychotics can still lead to TD. Examples include risperidone, olanzapine, quetiapine, and aripiprazole.
  • Other medications: Besides antipsychotics, other drugs can also cause TD. These may include certain antiemetic medications like metoclopramide, as well as some antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs).

What Are the Early Warning Signs?

Identifying the early warning signs is crucial to initiate appropriate management. The symptoms might be subtle at first, but they can gradually worsen if not addressed. Early warning signs of Tardive Dyskinesia include:

  • Repetitive Facial Movements: Involuntary movements like rapid blinking, grimacing, or lip smacking might appear and persist.
  • Tongue Abnormalities: You might notice your tongue sticking out, darting in and out, or making rolling movements.
  • Uncontrollable Jaw Movements: There might be jaw clenching or lateral movements of the jaw that can be distressing.
  • Choreoathetoid Movements: These are slow, writhing movements that can affect the fingers, hands, toes, and feet.
  • Involuntary Body Twisting: Your arms, legs, or torso may experience jerking or twisting motions.
  • Gait Disturbances: You may experience difficulties with walking or an unsteady gait.
  • Speech Problems: Some individuals might notice changes in their speech patterns, such as slurring or rapid speech.

Who is at Risk?

Tardive Dyskinesia is more likely to occur in individuals who have been taking antipsychotic medications for an extended period, typically for several months or years. However, not everyone who takes these drugs will develop the condition. Several factors may increase the risk including:

  • Long-term Medication Use: The risk increases with the duration of antipsychotic medication use. Those who take these medications for an extended period, typically several months or years, are more susceptible.
  • Type of Medication: First-generation or “typical” antipsychotics, such as haloperidol and chlorpromazine, have a higher risk compared to second-generation or “atypical” antipsychotics, such as risperidone and olanzapine. However, both types of drugs can still pose a risk.
  • High Dosages: Taking higher doses of antipsychotic medications can increase the likelihood of developing. Physicians often aim to prescribe the lowest effective dose to reduce this risk.
  • Older Age: Elderly individuals are at higher risk, especially those who have been on antipsychotic medications for an extended period.
  • Gender: Women appear to be at a slightly higher risk of developing compared to men.
  • Underlying Medical Conditions: Certain psychiatric and neurological conditions, such as mood disorders, schizophrenia, and Huntington’s disease, can increase the risk of TD.
  • Genetics: Some individuals may have a genetic predisposition that makes them more susceptible to developing when exposed to antipsychotic medications.

It is crucial for individuals taking antipsychotic medications, especially those with underlying risk factors, to be closely monitored by healthcare professionals for early signs of TD. If any abnormal movements are noticed, it is essential to seek medical attention promptly to adjust the treatment plan and prevent further complications.

What are the Treatments?

If you or a loved one is experiencing early signs of Tardive Dyskinesia, seeking medical attention promptly is essential. Early intervention can help manage the symptoms and prevent further deterioration.

  • Medication Adjustment: In some cases, the healthcare provider may adjust the dosage of the antipsychotic medication or switch to a different type with a lower risk of causing TD. This can help in reducing the severity of symptoms or even lead to their improvement.
  • Anticholinergic Medications: These medications can be prescribed to help control some of the involuntary movements. Anticholinergic drugs work by blocking certain chemical signals in the brain that contribute to abnormal movements.
  • Valbenazine and Deutetrabenazine: These are specific medications approved by the FDA for the treatment. They work by reducing the amount of dopamine in certain brain regions, helping to alleviate abnormal movements.
  • Clozapine: In some cases, switching to clozapine, an atypical antipsychotic with a lower risk, may be considered for individuals who do not respond well to other treatment options.
  • Deep Brain Stimulation (DBS): For severe and resistant cases, DBS may be considered. This is a surgical procedure that involves implanting electrodes in specific areas of the brain to help regulate abnormal movements.
  • Behavioral Therapy: Counseling or behavioral therapy sessions can help individuals cope with the emotional and social challenges. This can provide support and enhance the individual’s ability to manage their condition effectively.
  • Supportive Care: Physical therapy and occupational therapy may be beneficial in improving motor control and functionality. Supportive care can also address any secondary complications arising, such as difficulties with eating or speaking.
  • Regular Monitoring: Regular follow-up appointments with healthcare professionals are essential to monitor the progression and adjust the treatment plan as needed.

Find Cure For Tardive Dyskinesia Today

Recognizing the early warning signs of Tardive Dyskinesia is vital for early intervention and improved management. If you or someone you know is taking antipsychotic medications and experiencing any unusual movements, seek medical attention promptly. Understanding the risk factors can also help individuals and healthcare providers make informed decisions about treatment options. With appropriate care and management, individuals can lead fulfilling lives while minimizing the impact of this neurological disorder. To see early warning signs of Tardive Dyskinesia now, start an online search.

References:

  1. https://emedicine.medscape.com/article/1151826-overview?form=fpf
  2. https://www.webmd.com/mental-health/tardive-dyskinesia
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003252/
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